{"id":129869,"date":"2024-12-09T09:45:37","date_gmt":"2024-12-09T14:45:37","guid":{"rendered":"https:\/\/wfh.org\/?p=129869"},"modified":"2025-01-06T11:16:22","modified_gmt":"2025-01-06T16:16:22","slug":"une-equipe-internationale-dexpert%c2%b7es-publie-un-article-sur-les-approches-opposees-de-la-mise-en-oeuvre-stricte-du-systeme-grade-afin-declairer-les-lignes-directrices-de-prise-en","status":"publish","type":"post","link":"https:\/\/wfh.org\/fr\/article\/une-equipe-internationale-dexpert%c2%b7es-publie-un-article-sur-les-approches-opposees-de-la-mise-en-oeuvre-stricte-du-systeme-grade-afin-declairer-les-lignes-directrices-de-prise-en\/","title":{"rendered":"Une \u00e9quipe internationale d\u2019expert\u00b7es publie un article sur les approches oppos\u00e9es de la mise en \u0153uvre stricte du syst\u00e8me GRADE afin d\u2019\u00e9clairer les lignes directrices de prise en charge clinique"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"129869\" class=\"elementor elementor-129869 elementor-129825\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-af15e28 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"af15e28\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bb2c803\" data-id=\"bb2c803\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-193cb89 elementor-widget elementor-widget-text-editor\" data-id=\"193cb89\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.23.0 - 25-07-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Le syst\u00e8me GRADE est une m\u00e9thode rigoureuse et reconnue d\u2019\u00e9valuation des donn\u00e9es probantes, qui prend en compte des facteurs tels que la conception des \u00e9tudes, le risque de biais et le biais de publication. Il propose un processus transparent pour d\u00e9velopper des recommandations fond\u00e9es sur des preuves fiables. Cependant, l\u2019application de la m\u00e9thode GRADE au d\u00e9veloppement de lignes directrices de pratique clinique dans le contexte de maladies rares est plus complexe et peut exiger des adaptations particuli\u00e8res. L\u2019article \u00ab\u00a0Contrasting Approaches in the Implementation of GRADE Methodology in Guidelines for Haemophilia and von Willebrand Disease\u00a0\u00bb examine l\u2019utilisation incorrecte de la m\u00e9thodologie GRADE dans l\u2019\u00e9laboration des lignes directrices de l\u2019ISTH pour le traitement de l\u2019h\u00e9mophilie. Cet article a \u00e9t\u00e9 publi\u00e9 par une \u00e9quipe de 48 parties prenantes du domaine \u2013 expert\u00b7es de l\u2019h\u00e9mophilie, chercheurs et chercheuses, m\u00e9decins, patient\u00b7es et d\u00e9fenseur\u00b7es des patient\u00b7es, qui repr\u00e9sentent un grand nombre d\u2019organisations du monde entier, notamment l\u2019AICE, l\u2019AHAD-AP, l\u2019AHCDC, l\u2019ATHN, le CLAHT, l\u2019EHC, la F\u00e9d\u00e9ration mondiale de l\u2019h\u00e9mophilie (FMH), le CRH fran\u00e7ais et la MHEMO, le HTCCNC, la NBDF, le PEDNET et la UKHCDO.<\/p>\n<p>Voici un r\u00e9sum\u00e9 en termes simples de \u00ab\u00a0Contrasting Approaches in the Implementation of GRADE Methodology in Guidelines for Haemophilia and von Willebrand Disease\u00a0\u00bb. Pour lire la version int\u00e9grale (en anglais), <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/hae.15136\" target=\"_blank\" rel=\"noopener\">cliquez ici<\/a>.<\/p>\n<p style=\"padding-left: 80px;\">New guidelines for the management of hemophilia have recently been released by the ISTH, generating numerous reactions throughout the global community. These guidelines were developed by strictly applying the most rigorous approach of the methodology approach called GRADE, which only considers the results of so-called randomized clinical trials as valid. These studies compare the effectiveness of several treatments administered to patients, ideally selected randomly. However, such studies are very rare in hemophilia and often difficult to conduct due to the rarity and heterogeneity of the disease.<\/p>\n<p style=\"padding-left: 80px;\">The strict application of GRADE has led the ISTH to develop guidelines proposing limited, conservative, and unambitious therapeutic principles for hemophilia which fail to consider newer treatment options.<\/p>\n<p style=\"padding-left: 80px;\">This article highlights the missed opportunities by these ISTH guidelines. It presents a substantial number of arguments showing that adaptation of GRADE methodology could have been possible and valuable in this field. This approach should have included the plethora of scientific data available from registries and real-world studies. It should have also integrated the multiple patients-related outcome data, without overlooking the perspectives of experts familiar with these innovations. Such a scientifically validated use of GRADE, applied to other diseases, could have resulted in guidelines that reflect the true potential of new therapeutic options for hemophilia and, above all, meet the legitimate aspirations of an entire community.<\/p>\n<p>Pour lire l\u2019article \u00ab Contrasting Approaches in the Implementation of GRADE Methodology in Guidelines for Haemophilia and von Willebrand Disease\u201d \u00bb, <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/hae.15136\" target=\"_blank\" rel=\"noopener\">cliquez ici<\/a>. Pour lire la 3<sup>e<\/sup> \u00e9dition des Lignes directrices de la FMH pour la prise en charge de l\u2019h\u00e9mophilie, <a href=\"https:\/\/guidelines.wfh.org\/fr\/\" target=\"_blank\" rel=\"noopener\">c\u2019est ici<\/a>.<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Un article vient d\u2019\u00eatre publi\u00e9 dans la revue Haemophilia pour souligner l\u2019impact de la mise en \u0153uvre de la m\u00e9thodologie GRADE (Grading of Recommendations Assessment, Development and Evaluation) sur le d\u00e9veloppement de lignes directrices m\u00e9dicales. Cet article propose un examen critique des lignes directrices de l\u2019ISTH pour le traitement de l\u2019h\u00e9mophilie et met en lumi\u00e8re les limites et les opportunit\u00e9s manqu\u00e9es, dans le cadre sp\u00e9cifique de l\u2019application stricte de la m\u00e9thodologie GRADE dans ce document.<\/p>\n","protected":false},"author":13,"featured_media":129761,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[157],"tags":[],"search-category":[85],"class_list":["post-129869","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medical-news","search-category-article"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v23.4 (Yoast SEO v23.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Une \u00e9quipe internationale d\u2019expert\u00b7es publie un article sur les approches oppos\u00e9es de la mise en \u0153uvre stricte du syst\u00e8me GRADE afin d\u2019\u00e9clairer les lignes directrices de prise en charge clinique | FMH - F\u00e9d\u00e9ration mondiale de l\u2019h\u00e9mophilie<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wfh.org\/fr\/article\/une-equipe-internationale-dexpert%c2%b7es-publie-un-article-sur-les-approches-opposees-de-la-mise-en-oeuvre-stricte-du-systeme-grade-afin-declairer-les-lignes-directrices-de-prise-en\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Une \u00e9quipe internationale d\u2019expert\u00b7es publie un article sur les approches oppos\u00e9es de la mise en \u0153uvre stricte du syst\u00e8me GRADE afin d\u2019\u00e9clairer les lignes directrices de prise en charge clinique\" \/>\n<meta property=\"og:description\" content=\"Un article vient d\u2019\u00eatre publi\u00e9 dans la revue Haemophilia pour souligner l\u2019impact de la mise en \u0153uvre de la m\u00e9thodologie GRADE (Grading of Recommendations Assessment, Development and Evaluation) sur le d\u00e9veloppement de lignes directrices m\u00e9dicales. Cet article propose un examen critique des lignes directrices de l\u2019ISTH pour le traitement de l\u2019h\u00e9mophilie et met en lumi\u00e8re les limites et les opportunit\u00e9s manqu\u00e9es, dans le cadre sp\u00e9cifique de l\u2019application stricte de la m\u00e9thodologie GRADE dans ce document.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/wfh.org\/fr\/article\/une-equipe-internationale-dexpert%c2%b7es-publie-un-article-sur-les-approches-opposees-de-la-mise-en-oeuvre-stricte-du-systeme-grade-afin-declairer-les-lignes-directrices-de-prise-en\/\" \/>\n<meta property=\"og:site_name\" content=\"FMH - F\u00e9d\u00e9ration mondiale de l\u2019h\u00e9mophilie\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/wfhemophilia\/\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-09T14:45:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-06T16:16:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/wfh.org\/wp-content\/uploads\/2024\/12\/ISTH-grade-article-header-FR.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"627\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Mitch Semienchuk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u00c9crit par\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mitch Semienchuk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/wfh.org\/fr\/article\/une-equipe-internationale-dexpert%c2%b7es-publie-un-article-sur-les-approches-opposees-de-la-mise-en-oeuvre-stricte-du-systeme-grade-afin-declairer-les-lignes-directrices-de-prise-en\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/wfh.org\/fr\/article\/une-equipe-internationale-dexpert%c2%b7es-publie-un-article-sur-les-approches-opposees-de-la-mise-en-oeuvre-stricte-du-systeme-grade-afin-declairer-les-lignes-directrices-de-prise-en\/\"},\"author\":{\"name\":\"Mitch Semienchuk\",\"@id\":\"https:\/\/wfh.org\/fr\/#\/schema\/person\/f57928f0dd0ca8906b81082895256d8f\"},\"headline\":\"Une \u00e9quipe internationale d\u2019expert\u00b7es publie un article sur les approches oppos\u00e9es de la mise en \u0153uvre stricte du syst\u00e8me GRADE afin d\u2019\u00e9clairer les lignes directrices de prise en charge clinique\",\"datePublished\":\"2024-12-09T14:45:37+00:00\",\"dateModified\":\"2025-01-06T16:16:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/wfh.org\/fr\/article\/une-equipe-internationale-dexpert%c2%b7es-publie-un-article-sur-les-approches-opposees-de-la-mise-en-oeuvre-stricte-du-systeme-grade-afin-declairer-les-lignes-directrices-de-prise-en\/\"},\"wordCount\":547,\"publisher\":{\"@id\":\"https:\/\/wfh.org\/fr\/#organization\"},\"image\":{\"@id\":\"https:\/\/wfh.org\/fr\/article\/une-equipe-internationale-dexpert%c2%b7es-publie-un-article-sur-les-approches-opposees-de-la-mise-en-oeuvre-stricte-du-systeme-grade-afin-declairer-les-lignes-directrices-de-prise-en\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/wfh.org\/wp-content\/uploads\/2024\/12\/ISTH-grade-article-header-FR.jpg\",\"articleSection\":[\"Medical news\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/wfh.org\/fr\/article\/une-equipe-internationale-dexpert%c2%b7es-publie-un-article-sur-les-approches-opposees-de-la-mise-en-oeuvre-stricte-du-systeme-grade-afin-declairer-les-lignes-directrices-de-prise-en\/\",\"url\":\"https:\/\/wfh.org\/fr\/article\/une-equipe-internationale-dexpert%c2%b7es-publie-un-article-sur-les-approches-opposees-de-la-mise-en-oeuvre-stricte-du-systeme-grade-afin-declairer-les-lignes-directrices-de-prise-en\/\",\"name\":\"Une \u00e9quipe internationale d\u2019expert\u00b7es publie un article sur les approches oppos\u00e9es de la mise en \u0153uvre stricte du syst\u00e8me GRADE afin d\u2019\u00e9clairer les lignes directrices de prise en charge clinique | FMH - 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