{"id":191948,"date":"2026-11-12T19:45:07","date_gmt":"2026-11-13T00:45:07","guid":{"rendered":"https:\/\/wfh.org\/article\/el-19o-taller-sobre-nttg-arranca-en-montreal\/"},"modified":"2026-11-13T14:49:59","modified_gmt":"2026-11-13T19:49:59","slug":"el-19o-taller-sobre-nttg-arranca-en-montreal","status":"publish","type":"post","link":"https:\/\/wfh.org\/es\/article\/el-19o-taller-sobre-nttg-arranca-en-montreal\/","title":{"rendered":"El 19\u00ba taller sobre NTTG arranca en Montreal"},"content":{"rendered":"\t\t
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El siguiente es un resumen de lo que tuvo lugar hoy, 12 de noviembre de 2026, durante el 19\u00ba Taller sobre nuevas tecnolog\u00edas y terapia g\u00e9nica (NTTG).<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Sesi\u00f3n 1 \u2013 Bienvenida y \u201cNuevas tecnolog\u00edas proteicas\u201d<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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El taller inici\u00f3 con una retrospectiva de 30 a\u00f1os de innovaci\u00f3n, desde vectores virales y prote\u00ednas de factor hasta terapias sin factor de reemplazo y terapia g\u00e9nica. Los ponentes se\u00f1alaron que los tratamientos actuales reducen considerablemente las hemorragias, pero no las eliminan por completo. Los nuevos mim\u00e9ticos del factor VIII y los agentes reequilibradores siguen mejorando la protecci\u00f3n, mientras que la terapia g\u00e9nica resulta m\u00e1s predecible en la hemofilia B que en la hemofilia A. El debate se centr\u00f3 en la seguridad, el riesgo de trombosis, el cambio de tratamiento, y la forma en la que deber\u00edan medirse los resultados relativos a las hemorragias.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Sesi\u00f3n 2 \u2013 \u201cTerapias g\u00e9nicas curativas con VAA\u201d<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Durante esta sesi\u00f3n se repasaron los avances y los desaf\u00edos pendientes en el campo de la terapia g\u00e9nica con virus adenoasociados (VAA). Los programas para la hemofilia B han demostrado una expresi\u00f3n duradera, mientras que la terapia g\u00e9nica con factor VIII contin\u00faa siendo m\u00e1s variable, con disminuci\u00f3n de la expresi\u00f3n y preocupaciones relacionadas con el h\u00edgado. Los ponentes abordaron la biolog\u00eda subyacente a estas diferencias, la composici\u00f3n de los vectores, las respuestas inmunol\u00f3gicas y la posible genotoxicidad. El debate enfatiz\u00f3 la importancia de mejorar el dise\u00f1o de los vectores, de comprender la expresi\u00f3n a largo plazo, y de incrementar la transparencia en torno a los resultados de los programas de terapia g\u00e9nica suspendidos.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Sesi\u00f3n 3 \u2013 \u201cOtros sistemas de administraci\u00f3n\u201d<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Los ponentes que participaron en esta sesi\u00f3n analizaron tecnolog\u00edas alternas para la administraci\u00f3n g\u00e9nica dise\u00f1adas a fin de mejorar la especificidad, la seguridad, la durabilidad y la posibilidad de repetir la dosis. Los enfoques abordados abarcan inserci\u00f3n g\u00e9nica mediante retrotransposones, nanopart\u00edculas lip\u00eddicas dirigidas, electroporaci\u00f3n de pl\u00e1smidos, microburbujas activadas por ultrasonido, c\u00e1psides sint\u00e9ticas e ingenier\u00eda de variantes de VAA modificados. El debate se centr\u00f3 en la forma en la que estas plataformas inciden en distintos tipos de c\u00e9lulas, en cu\u00e1nto podr\u00eda durar la expresi\u00f3n g\u00e9nica, y en c\u00f3mo podr\u00eda mejorarse la seguridad, en comparaci\u00f3n con los m\u00e9todos convencionales que utilizan VAA.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Sesi\u00f3n 4 \u2013 \u201cEdici\u00f3n g\u00e9nica\u201d<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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La sesi\u00f3n sobre edici\u00f3n g\u00e9nica abord\u00f3 tecnolog\u00edas basadas en la herramienta CRISPR \u2013entre ellas nucleasas, edici\u00f3n de bases y edici\u00f3n de calidad (prime editing<\/em>, en ingl\u00e9s)\u2013 y sus posibles aplicaciones a los trastornos de la coagulaci\u00f3n. Los ejemplos presentados abarcaron enfoques de edici\u00f3n personalizados, terapias para la hemofilia A, y correcci\u00f3n de la enfermedad de Von Willebrand (EVW) en modelos precl\u00ednicos. Los ponentes tambi\u00e9n abordaron aspectos tales como alteraciones gen\u00e9ticas imprevistas, riesgo de ediciones accidentales (off-target<\/em>, en ingl\u00e9s), consideraciones pedi\u00e1tricas y cambios en las directrices reglamentarias, a la vez que se mostraron cautelosamente optimistas respecto al potencial de durabilidad y viabilidad a gran escala de las terapias de edici\u00f3n g\u00e9nica.<\/p>\n

Para obtener m\u00e1s informaci\u00f3n acerca del 19\u00ba Taller sobre nuevas tecnolog\u00edas y terapia g\u00e9nica (NTTG) haga clic aqu\u00ed<\/a>.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"19th\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"19th\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Hoy, la Federaci\u00f3n Mundial de Hemofilia (FMH) marc\u00f3 30 a\u00f1os de innovaci\u00f3n cient\u00edfica con el arranque del 19\u00ba Taller sobre nuevas tecnolog\u00edas y terapia g\u00e9nica (NTTG), en Montreal, Canad\u00e1. Expertos de todo el mundo estar\u00e1n reunidos en la ciudad, del 12 al 13 de noviembre de 2026, a fin de explorar los avances m\u00e1s recientes en el tratamiento y la investigaci\u00f3n de la hemofilia.<\/p>\n","protected":false},"author":13,"featured_media":191924,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[119,49,331,335,122,231],"tags":[],"search-category":[85],"class_list":["post-191948","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-education-es","category-education","category-featured-1","category-featured-1-es","category-gene-therapy","category-gene-therapy-es","search-category-article"],"yoast_head":"\nEl 19\u00ba taller sobre NTTG arranca en Montreal | FMH - Federaci\u00f3n Mundial de Hemofilia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wfh.org\/es\/article\/el-19o-taller-sobre-nttg-arranca-en-montreal\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El 19\u00ba taller sobre NTTG arranca en Montreal\" \/>\n<meta property=\"og:description\" content=\"Hoy, la Federaci\u00f3n Mundial de Hemofilia (FMH) marc\u00f3 30 a\u00f1os de innovaci\u00f3n cient\u00edfica con el arranque del 19\u00ba Taller sobre nuevas tecnolog\u00edas y terapia g\u00e9nica (NTTG), en Montreal, Canad\u00e1. Expertos de todo el mundo estar\u00e1n reunidos en la ciudad, del 12 al 13 de noviembre de 2026, a fin de explorar los avances m\u00e1s recientes en el tratamiento y la investigaci\u00f3n de la hemofilia.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/wfh.org\/es\/article\/el-19o-taller-sobre-nttg-arranca-en-montreal\/\" \/>\n<meta property=\"og:site_name\" content=\"FMH - Federaci\u00f3n Mundial de Hemofilia\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/wfhemophilia\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-11-13T00:45:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-11-13T19:49:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/wfh.org\/wp-content\/uploads\/2022\/01\/Placeholder-Result-V1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Mitch Semienchuk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mitch Semienchuk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/wfh.org\\\/es\\\/article\\\/el-19o-taller-sobre-nttg-arranca-en-montreal\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/wfh.org\\\/es\\\/article\\\/el-19o-taller-sobre-nttg-arranca-en-montreal\\\/\"},\"author\":{\"name\":\"Mitch Semienchuk\",\"@id\":\"https:\\\/\\\/wfh.org\\\/es\\\/#\\\/schema\\\/person\\\/4aea5b13c1966452a640eef39423925b\"},\"headline\":\"El 19\u00ba taller sobre NTTG arranca en Montreal\",\"datePublished\":\"2026-11-13T00:45:07+00:00\",\"dateModified\":\"2026-11-13T19:49:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/wfh.org\\\/es\\\/article\\\/el-19o-taller-sobre-nttg-arranca-en-montreal\\\/\"},\"wordCount\":575,\"publisher\":{\"@id\":\"https:\\\/\\\/wfh.org\\\/es\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/wfh.org\\\/es\\\/article\\\/el-19o-taller-sobre-nttg-arranca-en-montreal\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/wfh.org\\\/wp-content\\\/uploads\\\/2026\\\/11\\\/NTGT-Day-1-article-header.jpg\",\"articleSection\":[\"Educaci\u00f3n\",\"Education\",\"Featured 1\",\"Featured 1 - 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